. 2017 Jul 17;7:5548. doi: 10.1038/s41598-017-04026-8

Table 1.

Relevant studies of the studied candidate miRNAs on human placental tissue or cell lines.

miRNA	Function	Pathologic or Physiologic condition/Exposure	Biological system	Regulation	Reference
miR-16	Cell cycle & apoptosis	Development	Placenta	+BW, −SGA & −NAS	66, 85
		Pre-eclampsia	Placenta	−	67
		Cigarrete smoke	Placenta	+	37
miR-20a	Cell proliferation & invasion, angiogenesis	Pre-eclampsia	Placenta & BeWo cells	+	68
		Pre-eclampsia	JEG-3 cells	+	69
		Trimester-specific PM_2.5	Placenta	+/−	65
miR-21	Cell cycle & proliferation	Development	Placenta	+BW & −SGA	70, 85
		Cigarrete smoke	Placenta	−	37
		Trimester-specific PM_2.5	Placenta	+/−	65
miR-34a	Cell growth & invasion	Placenta accreta	JAR cells & placenta	−	63
		Cervical cancer	BeWo & JAR cells	+	71
		Pre-eclampsia	Placenta	−	86
miR-146a	Inflammation	Development	Placenta	+MS	66
		Pre-eclampsia	Placenta	−	68
		BSA	Trophoblast cells	+	72
		Nicotine&BaP/Cigarrete smoke	TCL-1 cells & placenta	−	37
		Trimester-specific PM_2.5	Placenta	−	65
miR-210	Hypoxia/Oxidative stress	Preeclampsia	Placenta	+	73
miR-222	Angiogenesis	Pre-eclampsia	Placenta	+	67
		Gestational Diabetes	Placenta	−	74
		Trimester-specific PM_2.5	Placenta	−	65

BW: birth weight, NAS: neonatal attention scores, SGA: small gestational age, BeWo, JEG-3 & JAR cells: trophoblast choriocarcinoma cell lines, TCL-1 cells: extravillous trophoblast from choriodecidua of a term placenta, MS: movement scores, BSA: bisphenol A, BaP: Benzopyrene.