Table 3.
Changes (%) in placental relative miRNA expression associated with maternal pre-pregnancy BMI, gestational weight gain and BMI at delivery.
| miRNAs | Pre-pregnancy BMIa | Gestational weight gainb | BMI at deliveryb | |||
|---|---|---|---|---|---|---|
| % change (95% CI) | P-value | % change (95% CI) | P-value | % change (95% CI) | P-value | |
| Girls (n = 112) | ||||||
| miR-16 | −4.26 (−9.28, 1.05) | 0.12 | 0.57 (−3.11, 4.39) | 0.77 | −2.98 (−7.27, 1.51) | 0.19 |
| miR-20a | −5.85 (−10.91, −0.50) | 0.035 | 1.21 (−2.57, 5.13) | 0.54 | −3.87 (−8.25, 0.72) | 0.10 |
| miR-21 | −4.65 (−10.69, 1.80) | 0.16 | 0.98 (−3.48, 5.65) | 0.67 | −3.08 (−8.26, 2.39) | 0.27 |
| miR-34a | −8.85 (−15.22, −2.00) | 0.014 | −1.45 (−6.14, 3.46) | 0.56 | −7.90 (−13.32, −2.15) | 0.009 |
| miR-146a | −4.77 (−9.76, 0.50) | 0.078† | −2.60 (−6.92, 1.93) | 0.26¥ | −3.40 (−7.72, 1.13) | 0.14 |
| miR-210 | −4.95 (−11.19, 1.72) | 0.14† | −4.15 (−9.48, 1.49) | 0.15¥ | −4.64 (−9.94, 0.97) | 0.11 |
| miR-222 | −4.84 (−9.38, −0.09) | 0.049† | −1.99 (−5.95, 2.12) | 0.34¥ | −3.43 (−7.34, 0.65) | 0.10 |
| Boys (n = 99) | ||||||
| miR-16 | 0.20 (−6.35, 7.21) | 0.95 | 2.73 (−2.21, 7.91) | 0.29 | 0.99 (−5.36, 7.76) | 0.77 |
| miR-20a | −2.99 (−9.57, 4.07) | 0.40 | 2.31 (−2.80, 7.69) | 0.38 | −2.10 (−8.49, 4.74) | 0.54 |
| miR-21 | −2.58 (−9.85, 5.28) | 0.51 | 0.06 (−5.44, 5.89) | 0.98 | −2.61 (−9.55, 4.87) | 0.48 |
| miR-34a | 4.01 (−5.34, 14.29) | 0.42 | 2.03 (−4.26, 8.73) | 0.54 | 3.81 (−5.09, 13.55) | 0.42 |
| miR-146a | −1.97 (−8.14, 4.62) | 0.55 | 0.80 (−3.87, 5.70) | 0.74 | −1.74 (−7.66, 4.56) | 0.58 |
| miR-210 | −3.81 (−11.65, 4.71) | 0.37 | 5.45 (−0.89, 12.19) | 0.097 | −1.61 (−9.44, 6.91) | 0.70 |
| miR-222 | −0.76 (−6.76, 5.63) | 0.81 | 3.85 (−0.77, 8.69) | 0.11 | 0.84 (−5.08, 7.13) | 0.79 |
Estimates (95% confidence intervals) for a 1 kg/m2 increase in BMI or for a 1 kg increment in gestational weight gain.
aAdjusted for newborn’s ethnicity and gestational age, maternal age, smoking status, educational status, parity, gestational weight gain, health complications, delivery by C-section and outdoor temperature during the third trimester of pregnancy.
bAdjusted for same set of covariates except gestational weight gain.
†Additionally adjusted for the interaction between pre-pregnancy BMI and gestational weight gain. Estimate for a gestational weight gain of 14 kg (50th percentile).
¥Additionally adjusted for the interaction between pre-pregnancy BMI and gestational weight gain. Estimate for a pre-pregnancy BMI of 23 kg/m2 (50th percentile).