Table 4.

Changes (%) in placental miRNA (miR-146a, miR-210 and miR-222) expression in newborn girls in association with pre-pregnancy BMI at specific gestational weight gain values.

Gestational Weight Gain (kg)a	miR-146a		miR-210		miR-222
	% change (95% CI)	P-value	% change (95% CI)	P-value	% change (95% CI)	P-value
7	−9.12 (−15.40, −2.38)	0.01	−9.53 (−17.34, −0.98)	0.032	−8.31 (−14.07, −2.16)	0.01
11	−6.66 (−11.92, −1.09)	0.022	−6.94 (−13.50, 0.12)	0.057	−6.34 (−11.14, −1.29)	0.016
14	−4.77 (−9.76, 0.50)	0.078	−4.95 (−11.19, 1.72)	0.14	−4.84 (−9.38, −0.09)	0.049
18	−2.19 (−7.74, 3.70)	0.46	−2.23 (−9.18, 5.24)	0.55	−2.81 (−7.82, 2.48)	0.29
25	2.50 (−5.99, 11.76)	0.58	2.70 (−7.90, 14.53)	0.63	0.86 (−6.74, 9.08)	0.83

Estimates (95% confidence intervals) are given for a 1 kg/m² increase in BMI and adjusted for newborn’s ethnicity and gestational age, maternal age, smoking status, educational status, parity, gestational weight gain, interaction between pre-pregnancy BMI and gestational weight gain, health complications, delivery by C-section and outdoor temperature during third trimester.

^aThe gestational weight gain (kg) is indicated for 5^th, 25^th, 50^th, 75^th and 95^th percentiles.