Table 5.
Measured miRNAs related to key processes implicated in obesity.
| miRNA | Regulation | Function | Biological system | Target | Reference |
|---|---|---|---|---|---|
| miR-16 | ↑ | Inhibition of blood vessel formation & migration of trophoblast cells | Human Umbilical Vein Endothelial Cells | ↓CCNE1 & VEGFA | 75 |
| ↓ | Weight loss in severe obesity (surgery-induced) | Human Plasma | 22 | ||
| miR-20a | ↑ | Inhibition of spheroid cell sprouting, network formation & cell migration | Human Endothelial Cells | 76 | |
| ↑ | Adipogenesis | Mouse Adipocytes (3T3L1) | ↓Rb2 | 23 | |
| miR-21 | ↑ | Inhibition of cell proliferation, migration & tubulogenesis | Human Umbilical Vein Endothelial Cells | ↓RhoB | 77 |
| ↑ | Adipogenesis | Human Adipose tissue-derived mesenchymal Stem Cells (hASCs) | ↓TGFBR2 | 24 | |
| ↑ | Weight loss in severe obesity (surgery-induced) | Human Plasma | 22 | ||
| miR-34a | ↑ | Inhibition of angiogenesis by induction of senescence | Rat Endothelial Progenitor Cells | ↓SIRT1 | 78 |
| ↓ | Reduced adiposity | Murine White/Brown Adipose Tissue | ↑FGF21 & SIRT1 | 25 | |
| ↑ | Adipogenesis | Human mature adipocytes | 39 | ||
| miR-146a | ↑ | Weight loss in severe obesity (surgery-induced) | Human Plasma | 22 | |
| ↑ | Increased cell migration, tube formation & angiogenesis | Human Umbilical Vein Endothelial Cells | ↓CARD10 & NF-kB | 79 | |
| ↓ | Inflammation/ Increased insulin resistance | Human peripheral blood mononuclear cells (Diabetic patients)/ Human Serum | ↑TNFα/↑IL-8 & HGF | 26 | |
| miR-210 | ↓ | Decreased tubulogenesis & cell migration (normoxic conditions) | Human Umbilical Vein Endothelial Cells | 80 | |
| ↑ | Enhanced angiogenesis | Human endothelial cells | 36 | ||
| ↓ | Adipogenesis | Human mature adipocytes | 39 | ||
| ↑ | Maternal Obesity | Human placenta (girls) | ↑TNFα | 38 | |
| miR-222 | ↑ | Reduced tube formation, migration & wound healing | Human Umbilical Vein Endothelial Cells | ↓KIT & eNOS | 81, 82 |
| ↑ | Inhibition cell migration | Human Umbilical Vein Endothelial Cells | ↓ETS1 | 83 | |
| ↓ | Inflammation-mediated vascular growth factors | Human Endothelial Cells | ↑STAT5a | 45 | |
| ↓ | Adipogenesis | Human mature adipocytes | 39 | ||
| ↑ | Severe obesity | Human Plasma (men or children) | 22, 84 |
CARD10: Caspase Recruitment Domain Family, Member 10, CCNE1: Cyclin E1, eNOS: endothelial Nitric Oxide Synthase 3, ETS1: V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1, FGF21: Fibroblast growth factor 21, HGF: Hepatocyte growth factor, IL-8: Interleukin 8, NF-kB: Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, KIT: V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog, Rb2: Retinoblastoma-like protein 2, RhoB: Ras Homolog Family Member B, SIRT1: Sirtuin 1, STAT5a: Signal transducer and activator of transcription 5A, TGFBR2: Transforming Growth Factor, Beta Receptor II, TNFa: Tumor necrosis factor a, VEGFA: Vascular endothelial growth factor A.