Table 2.
Summary of polygenic scores derived from T-cells subsets (CD4+ and CD8+) and CD4/CD8 ratio by chromosome for LS sarcoidosis (384 cases and 2,086 controls) using unpruned sets.
| CHR | CD4+ | CD8+ | CD4/CD8 ratio | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nagelkerke R2 (%) | % of explained variance | C-statistic | SCORE P-value | Nagelkerke R2 (%) | % of explained variance | C-statistic | SCORE P-value | Nagelkerke R2 (%) | % of explained variance | C-statistic | SCORE P-value | |
| Baseline | 21.81% | 0.00% | 0.81 | 5.48E-73 | 21.81% | 0.00% | 0.81 | 5.48E-73 | 21.81% | 0.00% | 0.81 | 5.48E-73 |
| 1 | 21.85% | 0.04% | 0.81 | 5.33E-01 | 22.14% | 0.34% | 0.81 | 2.76E-02 | 22.03% | 0.22% | 0.81 | 7.64E-02 |
| 2 | 21.83% | 0.02% | 0.81 | 8.93E-01 | 21.83% | 0.02% | 0.81 | 9.05E-01 | 21.83% | 0.02% | 0.81 | 9.74E-01 |
| 3 | 21.93% | 0.12% | 0.81 | 2.10E-01 | 21.95% | 0.14% | 0.81 | 1.74E-01 | 21.84% | 0.03% | 0.81 | 7.14E-01 |
| 4 | 21.93% | 0.12% | 0.81 | 2.18E-01 | 21.83% | 0.02% | 0.81 | 8.77E-01 | 21.95% | 0.14% | 0.81 | 1.67E-01 |
| 5 | 21.83% | 0.03% | 0.81 | 7.44E-01 | 22.16% | 0.35% | 0.81 | 2.45E-02 | 21.99% | 0.18% | 0.81 | 1.20E-01 |
| 6 | 22.22% | 0.41% | 0.81 | 1.61E-02 | 29.41% | 7.60% | 0.83 | 5.62E-27 | 28.29% | 6.49% | 0.83 | 9.69E-23 |
| 7 | 21.83% | 0.02% | 0.81 | 9.27E-01 | 22.08% | 0.27% | 0.81 | 5.01E-02 | 21.96% | 0.15% | 0.81 | 1.55E-01 |
| 8 | 22.02% | 0.21% | 0.81 | 9.13E-02 | 22.02% | 0.21% | 0.81 | 8.64E-02 | 21.84% | 0.03% | 0.81 | 6.96E-01 |
| 9 | 21.97% | 0.16% | 0.81 | 1.44E-01 | 21.84% | 0.03% | 0.81 | 6.49E-01 | 21.83% | 0.02% | 0.81 | 9.30E-01 |
| 10 | 21.86% | 0.06% | 0.81 | 4.49E-01 | 21.88% | 0.07% | 0.81 | 3.63E-01 | 21.83% | 0.02% | 0.81 | 9.93E-01 |
| 11 | 21.88% | 0.08% | 0.81 | 3.49E-01 | 21.86% | 0.05% | 0.81 | 4.79E-01 | 21.83% | 0.02% | 0.81 | 7.71E-01 |
| 12 | 21.86% | 0.05% | 0.81 | 5.11E-01 | 22.30% | 0.50% | 0.81 | 7.29E-03 | 22.15% | 0.34% | 0.81 | 2.90E-02 |
| 13 | 21.94% | 0.13% | 0.81 | 1.88E-01 | 21.93% | 0.12% | 0.81 | 2.07E-01 | 21.83% | 0.02% | 0.81 | 8.98E-01 |
| 14 | 21.83% | 0.02% | 0.81 | 9.79E-01 | 21.85% | 0.04% | 0.81 | 5.28E-01 | 21.85% | 0.04% | 0.81 | 5.58E-01 |
| 15 | 21.84% | 0.03% | 0.81 | 6.36E-01 | 21.83% | 0.02% | 0.81 | 9.51E-01 | 21.85% | 0.04% | 0.81 | 5.89E-01 |
| 16 | 22.01% | 0.20% | 0.81 | 9.45E-02 | 21.83% | 0.02% | 0.81 | 8.04E-01 | 21.96% | 0.15% | 0.81 | 1.55E-01 |
| 17 | 22.03% | 0.22% | 0.81 | 7.73E-02 | 21.85% | 0.04% | 0.81 | 5.82E-01 | 22.15% | 0.34% | 0.81 | 2.64E-02 |
| 18 | 21.86% | 0.06% | 0.81 | 4.51E-01 | 21.84% | 0.03% | 0.81 | 6.83E-01 | 21.83% | 0.02% | 0.81 | 8.77E-01 |
| 19 | 21.87% | 0.06% | 0.81 | 4.35E-01 | 21.87% | 0.06% | 0.81 | 4.13E-01 | 21.85% | 0.04% | 0.81 | 5.90E-01 |
| 20 | 21.86% | 0.06% | 0.81 | 4.51E-01 | 21.83% | 0.02% | 0.81 | 9.07E-01 | 21.86% | 0.05% | 0.81 | 4.72E-01 |
| 21 | 21.87% | 0.06% | 0.81 | 4.06E-01 | 21.91% | 0.10% | 0.81 | 2.67E-01 | 22.08% | 0.28% | 0.81 | 4.86E-02 |
| 22 | 21.88% | 0.07% | 0.81 | 3.70E-01 | 21.87% | 0.06% | 0.81 | 4.41E-01 | 21.91% | 0.10% | 0.81 | 2.60E-01 |
CHR = chromosome; P-value is the statistical significance appertaining to the derived polygenic score profile (SCOREprofile).