Table 5.
Summary of genetic contributions by non-LS and T-cells (CD4+ and CD8+) and CD4:CD8 ratio in significant polygenic scores derived using pruned sets.
| CHR | CD4 all-SNPs | CD4 genic-SNPs | CD4 intergenic-SNPs | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Num. of SNP predictors | 2 | 1652 | 671 | — | ||||||
| Non-LS-assoc, CD4-assoc, both, (%) | 4.00% | 5.02% | 0.36% | 4.17% | 5.37% | 0.45% | — | — | — | |
| Num. of SNP predictors | 5 | 1192 | — | — | ||||||
| Non-LS-assoc, CD4-assoc, both, (%) | 3.69% | 4.95% | 0.34% | — | — | — | — | — | — | |
| Num. of SNP predictors | 9 | — | 342 | — | ||||||
| Non-LS-assoc, CD4-assoc, both, (%) | — | — | — | 1.46% | 5.56% | 0.29% | — | — | — | |
| Num. of SNP predictors | 12 | 871 | — | — | ||||||
| Non-LS-assoc, CD4-assoc, both, (%) | 3.90% | 4.94% | 0.80% | — | — | — | — | — | — | |
| Num. of SNP predictors | 19 | 450 | — | 201 | ||||||
| Non-LS-assoc, CD4-assoc, both, (%) | 5.78% | 6.22% | 0.00% | — | — | — | 3.48% | 7.46% | 0.00% | |
| CD8 all-SNPs | CD8 genic-SNPs | CD8 intergenic-SNPs | ||||||||
| Num. of SNP predictors | 2 | 1652 | 671 | — | ||||||
| Non-LS-assoc, CD8-assoc, both, (%) | 4.00% | 5.02% | 0.36% | 4.17% | 5.37% | 0.45% | — | — | — | |
| Num. of SNP predictors | 7 | 995 | — | 527 | ||||||
| Non-LS-assoc, CD8-assoc, both, (%) | 4.02% | 4.82% | 0.40% | — | — | — | 4.36% | 5.12% | 0.57% | |
| Num. of SNP predictors | 14 | 617 | — | — | ||||||
| Non-LS-assoc, CD8-assoc, both, (%) | 4.86% | 3.40% | 0.49% | — | — | — | — | — | — | |
| Num. of SNP predictors | 16 | 665 | 365 | |||||||
| Non-LS-assoc, CD8-assoc, both, (%) | 2.41% | 4.96% | 0.45% | 3.84% | 6.85% | 0.00% | ||||
| CD4/CD8 all-SNPs | CD4/CD8 genic-SNPs | CD4/CD8 intergenic-SNPs | ||||||||
| Num. of SNP predictors | 9 | — | — | 457 | ||||||
| Non-LS-assoc, CD4/CD8-assoc, both, (%) | — | — | — | — | — | — | 2.19% | 7.22% | 0.22% | |
| Num. of SNP predictors | 12 | 871 | — | — | ||||||
| Non-LS-assoc, CD4/CD8-assoc, both, (%) | 3.90% | 4.94% | 0.80% | — | — | — | — | — | — | |
| Num. of SNP predictors | 20 | — | — | 283 | ||||||
| Non-LS-assoc, CD4/CD8-assoc, both, (%) | — | — | — | — | — | — | 4.24% | 4.59% | 0.00% | |
| Num. of SNP predictors | 21 | 243 | — | 155 | ||||||
| Non-LS-assoc, CD4/CD8-assoc, both, (%) | 8.23% | 4.94% | 0.00% | — | — | — | 10.32% | 3.87% | 0.00% | |