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. 2017 Jul 17;7:5517. doi: 10.1038/s41598-017-04811-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of prognostic genes with T stage stratification. (A) Kaplan-Meier curve for overall survival in HCC patients with different T stages from TCGA LIHC dataset. Patients were divided into 3 groups according to the T stages (T1, n = 176; T2, n = 89; T3 and T4, n = 92). Advanced T stage is a significant factor for poor prognosis (p < 0.0001, log-rank test). (B) All HCC patients were divided into three groups based on the T stages, and Kaplan-Meier survival analysis was performed in each group separately. Two subgroup were separated on the basis of the median expression level of each gene. 617 survival-related genes were obtained from T1 group, and 672 genes from T2 group, 1590 genes from T3/4 group. 15 common genes were found in different groups. (C) Cluster analysis of the 13 survival related genes based on the spearman correlation coefficient. The color in the heatmap represents spearman correlation coefficient. Red indicates positive correlation, and blue indicates negative correlation. 13 genes were clustered into 4 clusters, and RTN3, SOCS2, UPB1 (marked in red) were in different groups.