Table 2.
Cardiac parameters for WT and AC9−/− mice.
| Parameter# | WT | AC9−/− | P value |
|---|---|---|---|
| Mitral flow doppler | |||
| Peak velocity, E’ (mm/s) | 20 +/− 1 | 15 +/− 1 | 0.004 |
| Peak velocity, A’ (mm/s) | 16.5 +/− 0.6 | 16.3 +/− 0.5 | n.s. |
| Aortic ejection time (AET, ms) | 51 +/− 2 | 52 +/− 1 | n.s. |
| Isovolumic Relaxation Time (ms) | 24 +/− 2 | 27 +/− 2 | n.s. |
| Isovolumic Contraction Time (ms) | 20 +/− 1 | 20 +/− 1 | n.s. |
| Mitral valve A (cm/s) | 41 +/− 2 | 43 +/− 2 | n.s. |
| Mitral valve E (cm/s) | 64 +/− 2 | 54 +/− 2 | 0.005 |
| A’/E’ | 0.88 +/− 0.05 | 1.2 +/− 0.1 | 0.04 |
| MV E/A | 1.57 +/− 0.08 | 1.27 +/− 0.07 | 0.01 |
| MV E/E’ | 33 +/− 1 | 38 +/− 3 | n.s., 0.1 |
| Myocardial Performance Index (MPI) | 0.9 +/− 0.1 | 0.9 +/− 0.1 | n.s. |
#Mean +/− SE is given for male animals 3–7 months.