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. 2017 Jul 17;7:5568. doi: 10.1038/s41598-017-05537-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alternative exon usage in tumor subtypes compared to NBS. The number of exons identified as differentially spliced or transcribed in each tumor class compared to NBS with (A) higher FC, and (B) lower FC. The number of genes represented by the called exons is shown for each tumor subtype in (C and D). Many genes include both higher and lower FC exons. The number of genes representing the exons that are unique to subtype include both genes with differential usage of unique exons in one subtype only, as well as exons with different usage in two subtypes (+1 in one subtype, −1 in another) (E). The overlapping genes undergo distinct transcriptional and/or post-transcriptional events of specific exons in a subtype specific manner.