Table 1.
Demographics of 17 MIBC patients.
| Pt IDs | Age at TUR | Sex | No. of Samples Collected | TUR Grade | TUR & Imaging Stage | Post TUR Diagnostic Cystoscopy | Definitive Treatment | Final Pathology | Time to Recurrence | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TUR | BUF | PLS | UCP | USN | |||||||||
| 2 | 57 | M | 1 | 1 | 4 | 4 | 4 | 3 | T3N0M0 | 3 | CR | — | |
| 7 | 48 | F | 1 | 1 | 6 | 5 | 6 | 3 | T3N0M0 | 0 | RC + LND | T0N0 | |
| 8 | 76 | M | 1 | 1 | 5 | 4 | 5 | 3 | T3N0M0 | 0 | RC + LND | T0N0 | |
| 9 | 71 | F | 1 | 1 | 5 | 4 | 5 | 3 | T3N0M0 | 2 | RC + LND | T3N0 | 378 |
| 11 | 49 | F | 1 | 1 | 5 | 5 | 5 | 3 | T2N0M0 | 2 | RC + LND | T0 | Other* |
| 12 | 66 | M | 1 | 1 | 4 | 4 | 4 | 3 | T2N0M0 | 2 | Rad | — | 269 |
| 13 | 58 | M | 1 | 1 | 5 | 5 | 5 | 3 | T3N0M0 | 1 | RC + LND | T2N1 | 507 |
| 15 | 66 | F | 0 | 1 | 6 | 5 | 6 | 3 | T3N1M0 | 3 | RC + LND | T3N2 | 293 |
| 18 | 56 | M | 1 | 1 | 6 | 6 | 6 | 2 | T4N0M0 | 2 | RC + LND | T3N2 | 264 |
| 19 | 57 | M | 1 | 1 | 6 | 5 | 5 | 3 | T3N0M0 | 1 | RC + LND | T0N0 | |
| 21 | 64 | F | 1 | 1 | 4 | 4 | 4 | 3 | T3N0M0 | 2 | RC + LND | T0 | 466 |
| 24 | 66 | M | 1 | 1 | 5 | 5 | 5 | 3 | T3N0M0 | 1 | RC + LND | T0 N1 | |
| 26 | 50 | M | 1 | 1 | 6 | 6 | 6 | 3 | T3N0M0 | 1 | Partial RC + Rad | T3 | 472 |
| 27 | 58 | M | 1 | 1 | 4 | 3 | 4 | 3 | T3N2M0 | 2 | RC | T0 | |
| 29 | 59 | M | 1 | 1 | 6 | 6 | 6 | 3 | T3N0M0 | ND | RC + LND | T3 | |
| 32 | 65 | M | 1 | 1 | 5 | 3 | 4 | 3 | T3N0M0 | 1 | RC + LND | T3 | 283 |
| 33 | 70 | M | 1 | 1 | 4 | 4 | 4 | 3 | T3N1M0 | 0 | 1. CR 2. LND | N0 | |
The median age at time of TUR was 59 with the cohort consisting of 12 males (M) and 5 females (F), in keeping with the prevalence of BC. The number of TUR, BUF, PLS, UCP and USN samples obtained for each patient are presented. All patients with MIBC had high-grade (G2-3), locally advanced disease and opted for Radical Cystectomy (RC). Furthermore, 8/17 patients had early recurrence (median 336 days, ranging from 264 to 507). One patient (*) died shortly after surgery due to surgical complication and was thus excluded from further analysis involving correlations with early recurrence outcome. TUR and imaging stage information and final pathology are provided as per TNM criteria. CR – Chemoradiotherapy, Rad – Radiotherapy, LND – Lymph Node Dissection, ND – Not done.