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. 2017 Jul 17;7:5577. doi: 10.1038/s41598-017-06031-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Visualization of meningeal lymphatic vessels in Prox1-EGFP rat. Meninges from Prox1-EGFP rats were dissected and imaged as a whole mount. (A) Simplified diagram showing the lymphatics (green) positioned along the veins (superior sagittal and transverse sinuses) and artery (middle meningeal artery) of the rodent meninges. (B) Overview of whole mount meninges. SSS: Superior Sagittal Sinus, TS: Transverse Sinus, MMA: Middle Meningeal Artery, CR: Cerebellar Ring. (C) Lymphatic vessels were easily detected in the area of the middle meningeal artery. (D) Scheme of the meninges anatomy. The pia is localized on top of the brain parenchyma, the dura mater lines the skull, and the arachnoid matter lies between the pia and dura mater. The meningeal lymphatics are localized within the dura matter along the sinuses. Lymphatics were also clearly detectable in superior sagittal sinus (E), cerebellar ring (F), and transverse sinus (G). (H) Lymphatics in the cerebellar ring are enlarged in panel (F). Scale bars: 2 mm (B), 500 µm (C,F,G), 300 µm (E), 30 µm (H).