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. 2017 Jul 17;7:5599. doi: 10.1038/s41598-017-06098-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MLN4924 induces cell apoptosis in ccRCC cells. (a) Cells were treated with MLN4924 for 12 hrs, stained with Annexin-V-FITC and PI, and examined with flow cytometry assays. The percentages of ACHN and A498 cells in apoptosis are shown in (b). (c) Cells were treated with MLN4924 for 12 hrs, and levels of actived-caspase-3, Bax and Noxa were analyzed by western blotting in the whole cell lysates.