Table 2.
Summary of HR of miRNA expression in bladder cancer.
| Study | miR | Case number | OS | CSS | RFS | DFS/PFS | Expression associates with bad prognosis | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| High level | Low level | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |||
| Veerla 2009 | 452 | 11 | 23 | 8.6 (3.6–13.6) | < 0.025 | — | — | — | — | — | — | High |
| 452* | 11 | 23 | 8.2 (3.2–13.2) | < 0.025 | — | — | — | — | — | — | High | |
| Dyrskjøt 2009 | 133b | — | — | — | — | — | — | — | — | 3.5 (1.58–7.75)P | 0.002 | High |
| 518c* | — | — | — | — | — | — | — | — | 3.2 (1.49–6.89)P | 0.003 | High | |
| 129 | — | — | — | — | — | — | — | — | 3.0 (1.19–7.56)P | 0.02 | High | |
| 29c | — | — | — | — | — | — | — | — | 0.48 (0.23–1)P | 0.05 | High | |
| Wang 2012 | 100 | 48 | 78 | 0.10 (0.04–0.6) | 0.008 | — | — | — | — | 0.12 (0.04–0.77)P | 0.01 | Low |
| Yun 2012 | 200 | — | — | — | — | — | — | 0.449 (0.239–0.842) | 0.013 | — | — | Low |
| Zaravinos 2012 | 21 | 38 | 39 | 8.40 (1.90–37.04) | 0.005 | — | — | 4.88 (1.17–20.41) | 0.03 | — | — | High |
| 210 | 38 | 39 | 4.35 (1.13–16.67) | 0.033 | — | — | — | — | — | — | High | |
| 387 | 38 | 39 | 0.14 (0.03–0.65) | 0.012 | — | — | 0.17 (0.03–0.85) | 0.031 | — | — | Low | |
| Puerta-Gil 2012 | 222 | 56 | 57 | 1.96 (1.10–3.48) | 0.023 | 1.99 (1.05–3.76) | 0.034 | 2.08 (1.23–3.52) | 0.006 | 3.54 (1.54–8.18)P | 0.003 | High |
| 143 | 56 | 57 | — | — | — | — | 2.28 (1.21–4.31) | 0.011 | 3.01 (1.06–8.59)P | 0.039 | High | |
| Kim 2013 | 214 | 69 | 69 | — | — | — | — | 0.497 (0.254–0.974) | 0.041 | — | — | Low |
| Wang 2013 | 31 | 56 | 70 | 0.084 (0.033–0.833) | 0.008 | — | — | — | — | 0.114 (0.039–1)P | 0.01 | Low |
| Rosenbeg 2013 | 29c* | 18 | 57 | — | — | — | — | — | — | 0.2 (0.08–0.52)P | < 0.001 | Low |
| Ratert 2013 | 141 | 20 | 20 | 0.28 (0.09–0.82) | 0.02 | — | — | — | — | — | — | Low |
| 205 | 20 | 20 | 0.36 (0.13–0.95) | 0.04 | — | — | — | — | — | — | Low | |
| Pignot 2013 | 9 | 36 | 36 | 2.37 (1.36–4.15) | 0.003 | — | — | 1.86 (1.08–3.12) | 0.025 | — | — | High |
| 182 | 36 | 36 | 1.95 (1.09–3.47) | 0.024 | — | — | 1.95 (1.11–3.43) | 0.021 | — | — | High | |
| 200 | 36 | 36 | 1.86 (1.02–3.39) | 0.043 | — | — | 1.93 (1.09–3.39) | 0.023 | — | — | High | |
| Zhang 2014 | 101 | 46 | 26 | 0.451 (0.237–0.735) | 0.028 | — | — | — | — | — | — | Low |
| Zhang 2014 | 222 | 48 | 49 | 6.17 (2.33–10.39) | < 0.001 | — | — | — | — | — | — | High |
| Lin 2014 | 26a | 56 | 70 | 0.185 (0.088–0.762) | 0.01 | — | — | — | — | 0.192 (0.0891–0.745)D | 0.01 | Low |
| Drayton 2014 | 27a | 70 | 69 | — | — | — | — | 0.98 (0.49–1.96) | 0.96 | 0.44 (0.22–0.88)P | 0.02 | Low |
| 27b | 63 | 76 | — | — | — | — | 0.94 (0.47–1.90) | 0.87 | 0.38 (0.18–0.80)P | 0.01 | Low | |
| Zhang 2015 | 203 | 79 | 29 | 0.359 (0.209–0.616) | < 0.001 | — | — | — | — | 0.154 (0.082–0.288)P | < 0.001 | Low |
| Zhang 2015 | 21 | 28 | 25 | 3.32 (1.16–4.74) | 0.018 | — | — | — | — | — | — | High |
| Wu 2015 | 424 | 53 | 71 | 0.40 (0.24–0.69) | 0.001 | — | — | — | — | 0.152 (0.066–0.350)D | < 0.001 | Low |
| Wang 2015 | 141 | 54 | 60 | — | — | 0.314 (0.108–0.946) | 0.039 | — | — | 0.492 (0.254–0.954)D | 0.036 | Low |
| Wang 2015 | 214 | 64 | 65 | 0.282 (0.160–0.495) | < 0.001 | — | — | 0.264 (0.149–0.468) | < 0.001 | — | — | Low |
| Wang 2015 | 155 | 52 | 50 | — | — | — | — | — | — | 7.7 (1.4–14.7)P | 0.009 | High |
| Jiang 2015 | 152 | 29 | 30 | — | — | — | — | 2.324 (1.093–4.940) | 0.028 | — | — | High |
| 148b-3p | 29 | 30 | — | — | — | — | 0.872 (0.419–1.812) | 0.713 | — | — | Low | |
| 3187–3p | 29 | 30 | — | — | — | — | 0.483 (0.227–1.028) | 0.059 | — | — | Low | |
| 15b-5p | 29 | 30 | — | — | — | — | 1.023 (0.494–2.120) | 0.951 | — | — | High | |
| 27a-3p | 29 | 30 | — | — | — | — | 0.721 (0.344–1.510) | 0.386 | — | — | Low | |
| 30a-5p | 29 | 30 | — | — | — | — | 0.677 (0.323–1.419) | 0.302 | — | — | Low | |
| Avgeris 2015 | 143 | — | — | 3.329 (1.346–8.236) | 0.009 | — | — | — | — | 5.990 (1.351–26.55)P | 0.018 | High |
| 145 | — | — | 2.426 (0.985–5.976) | 0.054 | — | — | — | — | 4.164 (1.178–14.80)P | 0.027 | High | |
| 224 | — | — | 4.168 (0.557–31.183) | 0.164 | — | — | — | — | 2.654 (0.944–7.460)P | 0.064 | High | |
| Andrew 2015 | 34a | 63 | 166 | — | — | — | — | 0.57 (0.34–0.93) | 0.029 | — | — | Low |
| Martínez-Fernández 2015 | 200 | 31 | 30 | — | — | — | — | 0.49 (0.25–0.97) | 0.041 | — | — | Low |
| Zhang 2016 | 155 | 130 | 32 | — | — | — | — | 3.497 (1.722–7.099) | 0.001 | 9.466 (1.210–74.066)P | 0.032 | High |
miR: microRNA; HR: hazard ratio; CI: confidence interval; OS: overall survival; CSS: cancer-specific survival; RFS: recurrence-free survival; PFS: progression-free survival;
DFS: disease-free survival; —: not reported.
DDFS; PPFS.