Table 1.
Demographic and clinical characteristics of heterozygous familial hypercholesterolemia patients.
| Characteristics | Probable FH N = 354 | Definite FH N = 1,378 | P |
|---|---|---|---|
| Men, % (n) | 50.0 (177) | 48.9 (674) | 0.715 |
| Age, years | 56.0 (49.0–64.5) | 50.0 (38.0–60.0) | <0.001 |
| Body mass index, kg/m2 | 26.7 (22.5–28.6) | 26.2 (24.0–28.9) | 0.006 |
| Waist circumference, cm | 93.0 (84.5–99.0) | 90.0 (78.0–97.0) | <0.001 |
| Total cholesterol, mg/dL | 300 (272–333) | 340 (298–395) | <0.001 |
| Triglycerides, mg/dL | 143 (99.5–194) | 105 (75.0–143) | <0.001 |
| HDL cholesterol, mg/dL | 54.0 (46.5–64.5) | 53.0 (44.0–64.0) | 0.753 |
| LDL cholesterol, mg/dL | 213 (190–251) | 260 (216–316) | <0.001 |
| Glucose, mg/dL | 91.0 (84.5–97.5) | 89.0 (81.0–98.0) | 0.051 |
| Tendon xanthomas, % (n) | 3.3 (12) | 35.2 (485) | <0.001 |
| Cardiovascular disease, % (n) | 11.9 (42) | 13.4 (185) | 0.489 |
| Hypertension, % (n) | 26.4 (93) | 17.7 (244) | <0.001 |
| Diabetes, % (n) | 9.1 (32) | 5.2 (71) | 0.006 |
| Age at diabetes diagnosis, years | 54.0 (50.8–60.0) | 52.5 (46.5–60.3) | 0.563 |
| Age at statin onset, years | 48.3 (37.0–56.0) | 41.0 (31.0–51.0) | <0.001 |
| Statin therapy, years | 5.0 (2.0–11.0) | 7.0 (3.0–13.0) | <0.001 |
Values are expressed as median (interquartile range) for continuous variables and percentage (n) for categorical variables.
HDL denotes high-density lipoprotein; LDL, low-density lipoprotein.