Table 2.
Demographic and clinical characteristics of heterozygous familial hypercholesterolemia patients with or without diabetes.
| Characteristics | Diabetes N = 103 | No diabetes N = 1,629 | P |
|---|---|---|---|
| Men, % (n) | 58.3 (60) | 48.6 (792) | 0.057 |
| Age, years | 64 (55.0–69.0) | 51.0 (40.0–60.0) | <0.001 |
| Body mass index, kg/m2 | 28.9 (25.3–33.3) | 25.5 (22.8–28.4) | <0.001 |
| Waist circumference, cm | 100 (92.0–108) | 89.0 (80.0–96.0) | <0.001 |
| Total cholesterol, mg/dL | 348 (291–395) | 331 (292–384) | 0.318 |
| Triglycerides, mg/dL | 189 (129–256) | 106 (78.0–155) | <0.001 |
| HDL cholesterol, mg/dL | 47.5 (35.0–59.0) | 53.0 (45.0–64.0) | <0.001 |
| LDL cholesterol, mg/dL | 255 (202–312) | 253 (211–300) | 0.960 |
| HbA1c*, % | 6.7 (6.2–7.4) | 5.5 (5.3–5.9) | <0.001 |
| Tendon xanthomas, % (n) | 32.0 (33) | 28.7 (468) | 0.487 |
| Positive genetic diagnosis, % (n) | 46.6 (48) | 64.6 (1052) | 0.005 |
| Cardiovascular disease, % (n) | 40.8 (42) | 11.3 (184) | <0.001 |
| Hypertension, % (n) | 64.1 (66) | 16.7 (271) | <0.001 |
| Age at diabetes diagnosis, years | 53.0 (48.0–60–0) | — | |
| Age at statin onset, years | 51.5 (43.0–59.0) | 42.0 (31.5–52.0) | <0.001 |
| Statin therapy, years | 10.0 (6.0–17.0) | 7.0 (2.5–12.0) | <0.001 |
*Values refer to 87 (84.5%) diabetics and 410 (25.2%) non-diabetics.