Table 5.
Factors associated with the presence of type 2 diabetes mellitus in genetically-defined heterozygous familial hypercholesterolemia patients (with a pathogenic mutation in LDLR, APOB or PCSK9 genes).
| Standard coeff. (β) | Exp (B) | 95% CI | p | R2 | |
|---|---|---|---|---|---|
| Sex, male | 0.713 | 2.041 | 1.081–3.853 | 0.028 | 0.195 |
| BMI, kg/m2 | 0.018 | 1.018 | 1.003–1.034 | 0.022 | |
| Hypertension, yes | 2.072 | 7.942 | 4.249–14.845 | <0.001 | |
| Statin therapy, years | 0.044 | 1.045 | 1.002–1.090 | 0.040 |
BMI denotes body mass index.
Independent variables included in the model: sex, age, BMI, smoking status, hypertension, tendon xanthomas, baseline LDL and HDL cholesterol and triglyceride concentrations, genetic diagnosis and statin therapy duration.