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. 2017 Jul 17;7:5570. doi: 10.1038/s41598-017-05766-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Physiological differences among UCP1 genotypes. (a) The physical positions and LD structure of UCP1 SNPs genotyped in this study. A pairwise r ² value is shown in each square. Darker gradient color indicates higher r ² values, and black indicates an r ² of 1. The haplotype block defined by the Gabriel et al. method³¹ is represented by the enclosure of the black line. (b) Time series variations of VO₂ (+/− s.e.m.) in each SNP and that genotype. The solid and dashed lines show the changes under 16 and 28 degrees Celsius, respectively. The colors of the lines represent each genotype (blue: a homozygote of an ancestral allele; magenta: a homozygote of a derived allele; green: heterozygote of ancestral/derived alleles). (c) Time series variations of VO₂ (+/− s.e.m.) between haplotypes. The solid and dashed lines show the changes under 16 and 28 degrees Celsius, respectively. The colors of the lines represent each genotype (red: a homozygote of GnGTAn haplotype; blue: a homozygote and heterozygote of other haplotypes). The asterisks indicate a significant increase compared with other genotypes (*P < 0.05; **P < 0.01).