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. 2017 Jul 17;7:5594. doi: 10.1038/s41598-017-06052-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation of betatrophin with insulin levels. Circulating betatrophin is associated with fasting insulin levels in all studied individuals (r = 0.497, P < 0.01) (A) and in T2D patients with insulin treatment (r = 0.541, P < 0.01) (B). Scatter plots illustrate correlation (r) between betatrophin and fasting insulin levels. ▴ illustrates patients with insulin treatment, and Δ illustrates patients without insulin treatment.