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. 2017 Jul 17;7:5604. doi: 10.1038/s41598-017-05515-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Molecular network from the extract of the bacterium Streptomyces CBR53 with the identification of the elaiophylin macrolide. (A) Molecular network after filter blanks, colors indicate producers of the nodes: Streptomyces CBR53 green; Escvopsis TZ49 blue, Streptomyces sp. vs Escovopsis sp. (CBR53 vs TZ49) red. Nodes found in more than one producers are represented as combination of their colors: Streptomyces CBR53, Streptomyces sp. vs Escovopsis sp. (CBR53 vs TZ49) yellow; Escovopsis TZ49, Streptomyces sp. vs Escovopsis sp (CBR53 vs TZ49) pink; Streptomyces CBR53, Escvopsis TZ49 cian. (B) Enlarged cluster of shearinine derivatives indicating their location in the sub-network, chemical structures of shearinine D, shearinine F and shearinine J. (C) Chemical structures of elaiophylin, efomycin G and efomycin A macrolides dereplicated using GNPS and AntiMarin, enlarged cluster denoting their location in the cluster.