Table 3.
Proportional hazards multivariate model (N = 205)
| Variable | Leukemia-free survival |
Overall survival |
Pulmonary toxicity |
|---|---|---|---|
| Hazard ratio (95% confidence interval) | |||
| Karnofsky performance status | 0.98 (0.96-1.00) | 0.98 (0.96-1.01) | 0.96 (0.93-0.99) |
| Pretransplant disease status | |||
| CR1 | 0.63 (0.40-0.98) | 0.72 (0.46-1.14) | 0.75 (0.38-1.48) |
| CR2-3 | 0.51 (0.33-0.79) | 0.55 (0.35-0.87) | 0.57 (0.27-1.22) |
| Refractory | Reference | Reference | Reference |
| Acute GVHD | 1.16 (0.80-1.69) | 1.27 (0.86-1.85) | 0.89 (0.51-1.54) |
| Successful engraftment | 0.17 (0.10-0.27) | 0.16 (0.10-0.27) | 0.38 (0.20-0.75) |
| Year of transplant | 0.91 (0.87-0.95) | 0.91 (0.87-0.95) | 0.97 (0.92-1.03) |
| Treatment group | |||
| Chemotherapy alone | Reference | Reference | Reference |
| TBI + chemotherapy | 0.63 (0.44-0.91) | 0.63 (0.43-0.91) | 5.19 (2.65-10.15) |