Table 2.
Comparative analysis of salvage treatments and associations with risk of radiation necrosis
| Group | OR for RN with 95% CI | P value |
|---|---|---|
| Any salvage vs no salvage | 2.37 (0.56-9.65) | .31 |
| Salvage SRS vs any salvage | 2.32 (0.72-7.49) | .21 |
| Salvage WBRT vs any salvage | 1.59 (0.49-5.09) | .55 |
| Salvage surgery vs any salvage | 0.63 (0.03-11.69) | .76 |
| Any salvage vs salvage SRS + WBRT | 5.73 (1.69-19.38) | .0075 |
| Salvage SRS vs salvage SRS + salvage WBRT | 18.2 (0.98-339.79) | .05 |
| Salvage WBRT vs salvage SRS + salvage WBRT | 3.77 (1.11-12.85) | .04 |
| Salvage SRS alone vs salvage WBRT alone | 1.86 (0.034-95.86) | .31 |
| Subgroups | ||
| All salvage WBRT dose ≥30 vs <30 | 4 (0.69-23.23) | .18 |
| All SRS lesions >4 vs 1-4 | 3.24 (0.35-29.58) | .39 |
Bold font indicates P < .05.
CI, confidence interval; RN, radiation necrosis; OR, odds ratio; SRS, stereotactic radiosurgery; WBRT, whole brain radiation therapy.