Table 2.
Acute toxicity noted in study patients and definitions of dose-limiting toxicities
| Acute radiation-related toxicities in study patients | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Grade | Nausea | Vomiting | Anorexia | Reflux | Diarrhea | Constipation | Flatulence | Fatigue | Skin | Neutropenia |
| 0 | 3 | 6 | 7 | 10 | 9 | 9 | 10 | 2 | 2 | 10 |
| 1 | 5 | 4 | 2 | 1 | 2 | 2 | 1 | 6 | 9 | 1 |
| 2 | 3 | 1 | 2 | 0 | 0 | 0 | 0 | 3 | 0 | 0 |
| 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Grade | Dose-limiting toxicity definition |
|---|---|
| ≥3 | Non-hematologic or hematologic toxicity that requires >7-day interruption in therapy (excluding alopecia and nausea/vomiting not controlled by optimal supportive care) |
| ≥4 | Non-hematologic toxicity |
| ≥4 | Neutropenia or thrombocytopenia |