Table 2.
Parameter estimates for the deconvolution-analysis-informed population model
| Parameter | Unit | Estimate [RSE%] (CV%) | Shrinkage (%) |
|---|---|---|---|
| ϴ Amplitude | mU/L/44.7% TBW | 7.86 [3.25] | – |
| ϴ k out | /h | 2.78 [3.46] | – |
| ϴ SecretionSD | h/44.7% TBW | 0.182 [3.14] | – |
| ϴ Baseline | mU/L/44.7% TBW | 0.185 [4.52] | – |
| ϴ A_0 | mU/L | 1.05 [5.03] | – |
| ϴ Exponent Amplitude | – | 3.4 [2.1] | – |
| ϴ Exponent SecretionSD | – | 2.32 [3.15] | – |
| ϴ Exponent Baseline | – | 4.29 [4.29] | – |
| ω2 Amplitude IIV | – | 0.22 (49.7) | 12.8 |
| ω2 Amplitude BOV-n | – | 2.32 (302) | – |
| ω2 k out | – | 0.0699 (26.9) | 2.02 |
| ω2 SecretionSD | – | 0.0715 (27.2) | 0.12 |
| ω2 Baseline | – | 0.406 (70.8) | <0.01 |
| ω2 A_0 | – | 3.34 (521) | 0.18 |
| σ2 proportional residual error | – | 0.106 | 5.61 |
RSE% relative standard error; CV% coefficient of variation; TBW total body water