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. 2017 May 11;44(4):389–400. doi: 10.1007/s10928-017-9526-0

Table 3.

Parameter estimates of the simulated and the re-estimated model

Parameter Simulated Re-estimated parameter estimates [RSE%] (CV%) Shrinkage (%)
ϴ E max −0.9 -0.929 [1.6]
ϴ EA 50 3 3.16 [7.4]
ϴ γ 5 5.04 [21]
ω2 EA 50 0.01 0.0363 (19.2) 51
σ2 proportional residual error 0.106 0.105 5.08

RSE% relative standard error; CV% coefficient of variation