Table 3.
Effects of metal cations and oxoanions on PTP1B activity
| Effector cation/oxyanion | Nature of modulation I:inhibition A:activation | Concentration with significant modulation | Modulation (%) |
|---|---|---|---|
| Zinc (Zn2+) | I | 10 μM | 95 |
| Cadmium (Cd2+) | I | 10 μM | 91 |
| Copper (Cu2+) | I | 5 μM | 99 |
| Lead (Pb2+) | I/A | 5 μM/1 mM | 96/87 |
| Silver (Ag+) | I | 50 μM | 92 |
| Iron (Fe2+) | I/A | 5 μM/500 μM | 77/74 |
| Iron (Fe3+) | I/A | 10 μM/500 μM | 71/68 |
| Chromium (Cr3+) | NSa | – | – |
| Lanthanum (La3+) | I/A | 1 μM/100 μM | 63/15 |
| Lithium (Li+) | NSa | – | – |
| Manganese (Mn2+) | NSa | – | – |
| Nickel (Ni2+) | NSa | – | – |
| Tetrathiomolybdate (MoS4 2−) | I | 100 μM | 97 |
| Tungstate (WO4 2−) | I | 500 μM | 62 |
| Nitrate (NO3 −) | I | 100 mM | 65 |
| Heptamolybdate (Mo7O24 6−) | I | 100 μM | 88 |
| Arsenate (AsO4 3−) | I | 500 μM | 66 |
| Chromate (CrO4 2−) | I | 500 μM | 81 |
| Borate (BO3 3−) | NSa | – | – |
| Carbonate (CO3 2−) | NSa | – | – |
a NS no significant effect. n = 3