Table 3.
Adiponectin, leptin, leptin/adiponectin ratio and resistin and in various types of dementia, MCI and controls
| Adipokines | Dementia | pa | AD | MD | VaD | MCI | Controls | pb |
|---|---|---|---|---|---|---|---|---|
| n = 205 | n = 89 | n = 69 | n = 47 | n = 113 | n = 107 | |||
| Adiponectin (μg/mL) | 10.20 [6.79–13.80] (9.44) |
0.002 (0.002) |
11.44 [7.28–15.71]** (9.19)*** |
10.30 [6.99–13.61]** (9.63)** |
8.39 [4.85–12.27] (8.39) |
8.12 [4.81–12.01] (8.69) |
8.23 [4.87–11.63] (7.66)c (7.45)d |
0.001 (0.019) |
| Leptin (ng/mL) | 8.66 [3.81–17.36] (7.99) |
0.357 (0.365) |
8.13 [4.15–15.38] (8.18) |
8.66 [3.81–17.40] (8.98) |
10.08 [3.36–19.62] (7.46) |
10.18 [5.01–17.32] (8.36) |
9.96 [5.48–15.36] (8.58)c (8.88)d |
0.551 (0.498) |
| L/A ratio | 0.83 [0.31–2.40] (0.85) |
0.015 (0.012) |
0.72 [0.31–2.01]# (0.89) |
0.93 [0.32–2.12] (0.93) |
1.05 [0.31–3.89] (0.89) |
1.33 [0.52–3.15] (0.96) |
1.31 [0.58–2.56] (1.12)c (1.19)d |
0.032 (0.149) |
| Resistin (ng/mL) | 9.22 [7.39–11.96] (9.37) |
0.00009 (0.005) |
8.32 [6.95–10.94] (9.15) |
9.87 [7.76–12.53]*** (9.78)*** |
9.62 [7.52–14.02]** (9.64)** |
8.29 [6.25–10.75] (8.56) |
8.43 [6.50–10.04] (8.29)c (8.33)d |
0.0001 (0.018) |
Data are logarithmically transformed in statistical analysis and presented as geometric means and interquartile range from first to third quartile
Values in parentheses are adjusted on age, sex, BMI, anti-diabetic, antihypertensive and lipid-lowering treatment (ANCOVA)
AD Alzheimer’s disease, L/A ratio leptin/adiponectin ratio, MCI mild cognitive impairment, MD mixed dementia, VaD vascular dementia
* p < 0.05, ** p < 0.01, *** p < 0.001, # borderline significant (0.1 > p > 0.05) versus Controls (ANOVA Dunnet post hoc test)
aStudent’s t test
bANOVA
cAdjusted values in controls versus all-cause dementia
dAdjusted values in controls versus various types of dementia and MCI