Table 6.

Factors affecting adiponectin, leptin, and resistin levels in whole investigated group (n = 425) based on multivariate stepwise regression analysis

Variables	Adiponectina			Leptina			Resistina
	β	ΔR2	p	β	ΔR2	p	β	ΔR2	p
HDL-Ca	0.282	0.232	<0.000001
HOMA-IRa	−0.213	0.087	<0.000001	0.207	0.035	<0.000001	–	–	–
Age	0.210	0.053	<0.000001				0.156	0.054	0.00001
Anti-diabetic therapy	−0.197	0.044	<0.000001
Sex	−0.183	0.026	0.00002	−0.452	0.182	<0.00001	−0.149	0.010	0.023
BMI	−0.115	0.012	0.003	0.569	0.414	<0.00001	–	–	–
AD	0.111	0.007	0.022
MD	0.140	0.009	0.008				0.101	0.006	0.037
VaD							0.141	0.012	0.015
IL-6a				–	–	–	0.123	0.022	0.001
hsCRPa	–	–	–	0.084	0.006	0.007	–	–	–
Creatinine							0.353	0.120	<0.00001
	R2 adj = 0.462, p < 0.00001			R2 adj = 0.634, p < 0.00001			R2 adj = 0.219 p < 0.00001

Sex (female = 0; male = 1).

Adiponectin: variables included in the model: age, sex, BMI, HDL cholesterol (HDL-C), HOMA-IR, hsIL-6, cognitive status (AD, MD, VaD, MCI) and anti-diabetic, anti-hypertensive and lipid-lowering therapy.

Leptin: variables included in the model: age, sex, BMI, HDL cholesterol (HDL-C), HOMA-IR, hsCRP, cognitive status (AD, MD, VaD, MCI) and anti-diabetic, anti-hypertensive and lipid-lowering therapy and cognitive status (AD, MD, VaD, MCI) and anti-diabetic, antihypertensive and lipid-lowering therapy.

Resistin: variables included in the model: age, sex, HDL cholesterol (HDL-C), IL-6, 25(OH)vitamin D, creatinine, serum chitotriosidase, current smoking, cognitive status (AD, MD, VaD, MCI) and anti-diabetic, anti-hypertensive and lipid-lowering therapy

β the standard regression coefficient, R ² adj the multiple coefficient of determination (adjusted), AD Alzheimer’s disease, BMI body mass index, CRP C-reactive protein, HDL-C high density lipoprotein cholesterol, HOMA-IR homeostatic model assessment index, IL-6 interleukin 6, MD mixed dementia, MMSE mini mental state examination, VaD vascular dementia

^aLogarithmically transformed in statistical analysis