Table 3.
Associations between PRD and survival after definitive RTa
| PRD level | Survival after RT (95% CI) |
Univariable analysis |
Multivariable analysisb |
|||
|---|---|---|---|---|---|---|
| 1 y after RT | 2 y after RT | HR (95% CI) | P value | HR (95% CI) | P value | |
| As a continuous variable | ||||||
| 3-unit increase | NA | NA | 1.34 (1.08-1.65) | .007 | 1.39 (1.11-1.74) | .004 |
| As a categorical variable | .11c | .10c | ||||
| Low distress, 0-3 (n = 295) | 90% (86%-94%) | 83% (77%-89%) | 1.00 (reference) | NA | 1.00 (reference) | NA |
| Moderate distress, 4-6 (n = 222) | 84% (79%-90%) | 73% (66%-81%) | 1.58 (1.02-2.44) | .042 | 1.62 (1.03-2.56) | .038 |
| High distress, 7-10 (n = 161) | 87% (81%-93%) | 74% (65%-84%) | 1.42 (0.88-2.30) | .15 | 1.49 (0.90-2.48) | .12 |
| Moderate or high distress, 4-10 (n = 383) | 85% (81%-89%) | 74% (68%-80%) | 1.51 (1.02-2.24) | .042 | 1.57 (1.03-2.38) | .034 |
CI, confidence interval; HR, hazard ratio; NA, not applicable; PRD, patient-reported distress; RT, radiation therapy.
a
HRs, 95% CIs, and P values were determined from Cox proportional hazards regression models.
b
Multivariable models were adjusted for age, sex, primary cancer site, RT dose, metastatic disease at the start of RT, chemotherapy at or before the start of RT, and surgery at or before the start of RT.
c
Test of overall difference.