Table 3.
Radiation toxicity, grading, duration, and outcome of initial symptoms
| Toxicitya | n = 28 |
|---|---|
| Urinary frequency | Total = 4 |
| Grade 2 (Talcottb) | 2 |
| Grade 3 (Talcottb) | 2 |
| Urinary irritation | Total = 1 |
| Grade 5 (Talcottc) | 1 |
| Urinary tract infection | Total = 4 |
| Grade 2 (Talcottd) | 1 |
| Grade 2 (CTCAE) | 1 |
| Grade 3 (CTCAE) | 1 |
| Unevaluable | 1 |
| Anemia | Total = 6 |
| Grade 1 (CTCAE) | 1 |
| Grade 2 (CTCAE) | 5 |
| Fatigue | Total = 15 |
| Grade 1 (CTCAE) | 10 |
| Grade 2 (CTCAE) | 5 |
| Skin | Total = 2 |
| Grade 3 (RTOG) | 2 |
| Diarrhea | Total = 1 |
| Grade 3 (Talcotte) | 1 |
| None | 4 |
| Unevaluable | 2 |
| Duration of toxicitya | n = 28 |
| ≤2 weeks | 7 |
| 3 weeks | 1 |
| >3 weeks to ≤1 month | 7 |
| 2-3 months | 4 |
| 6 months | 2 |
| Permanent | 2 |
| Unevaluable | 10 |
| Outcome of initial symptoms | n = 28 |
| Complete resolution | 24 |
| No symptom resolution | 2 |
| Unevaluable | 2 |
CTCAE, Common Toxicity Criteria for Adverse Events; RTOG, Radiation Therapy Oncology Group.
a
Patients can have more than one toxicity.
b
Talcott urinary frequencies: grade 5 = 9-12 times/day, grade 4 = 5-8 times/day. These do not meet RTOG criteria for grade 3 or 4 bladder toxicity.
c
Talcott urinary irritation: grade 3 = burning or pain during urination several times/day. These do not meet RTOG criteria for grade 3 or 4 bladder toxicity.
d
Talcott urinary tract infection: grade 2 = Burning with urination at least twice per day.
e
Talcott diarrhea: grade 3 = loose stool several times/day. This does not meet RTOG criteria for grade 3 or 4 lower gastrointestinal toxicity.