Table 1.
Significant lipids obtained from statistical analysis (VIP >1.5; P < .05) in RPs and NRPs at the t0 time point
| RT_m/z | VIP | NRPs |
RPs |
t test value | |||
|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | ||||
| PCs/SMs | 14.79_727.86 | 1.86 | 18.03 | 6.28 | 23.84 | 3.91 | 0.037 |
| 16.14_495.7 | 2.59 | 9.88 | 1.53 | 13.49 | 2.42 | 0.001 | |
| 15.72_480.42 | 2.27 | 1.46 | 0.62 | 2.24 | 0.39 | 0.008 | |
| 13.44_787.52 | 2.13 | 333.95 | 56.02 | 183.28 | 155.44 | 0.011 | |
| 13.51_798.84 | 1.96 | 2.21 | 4.71 | 8.47 | 6.02 | 0.025 | |
| 13.86_842.90 | 1.71 | 0.08 | 0.25 | 1.88 | 1.26 | 0.0001 | |
| 12.57_830.92 | 1.70 | 0.22 | 0.48 | 1.01 | 0.93 | 0.034 | |
| 12.58_806.35 | 1.87 | 0.25 | 0.43 | 1.53 | 1.78 | 0.042 | |
| 12.51_812.58 | 2.21 | 0.02 | 0.07 | 0.29 | 0.26 | 0.008 | |
| 14.75_757.37 | 1.83 | 1.72 | 2.14 | 0.00 | 0.00 | 0.038 | |
| 14.91_782.88 | 1.93 | 0.11 | 0.36 | 1.53 | 1.78 | 0.025 | |
| 14.04_715.12 | 1.89 | 0.04 | 0.14 | 0.40 | 0.50 | 0.047 | |
| PEs | 9.53_812.96 | 1.92 | 22.90 | 15.93 | 41.24 | 20.47 | 0.048 |
| 10.80_478.63 | 1.78 | 4.40 | 8.72 | 15.31 | 7.55 | 0.013 | |
| 9.83_723.00 | 1.78 | 3.15 | 6.77 | 12.80 | 9.44 | 0.023 | |
| 11.08_528.61 | 2.08 | 1.49 | 4.71 | 20.81 | 25.01 | 0.028 | |
| 11.54_750.09 | 2.46 | 0.63 | 2.01 | 7.78 | 7.04 | 0.007 | |
| 9.67_796.81 | 2.23 | 0.93 | 2.96 | 17.07 | 19.23 | 0.018 | |
| 9.23_502.71 | 2.39 | 7.47 | 7.17 | 0.00 | 0.00 | 0.010 | |
| 11.18_532.48 | 2.05 | 7.55 | 9.03 | 0.00 | 0.00 | 0.032 | |
| 12.35_454.71 | 1.96 | 0.73 | 2.31 | 6.06 | 7.27 | 0.043 | |
| 9.43_764.26 | 2.15 | 6.60 | 7.41 | 0.00 | 0.00 | 0.024 | |
| 8.01_555.83 | 1.92 | 3.24 | 4.22 | 0.00 | 0.00 | 0.046 | |
| 10.10_731.77 | 2.21 | 0.00 | 0.00 | 7.10 | 8.62 | 0.018 | |
| 7.60_792.30 | 1.91 | 3.81 | 4.98 | 0.00 | 0.00 | 0.047 | |
| 11.27_939.11 | 2.16 | 0.00 | 0.00 | 3.70 | 4.67 | 0.023 | |
| 12.36_808.91 | 1.98 | 0.00 | 0.00 | 3.24 | 4.61 | 0.039 | |
| PGs | 2.55_337.05 | 2.11 | 7.66 | 10.13 | 34.40 | 31.77 | 0.023 |
| 6.22_543.15 | 2.07 | 1.60 | 5.07 | 15.31 | 16.87 | 0.026 | |
| 5.77_763.48 | 1.86 | 2.73 | 8.65 | 22.98 | 28.48 | 0.048 | |
| 3.16_311.30 | 2.01 | 1.15 | 3.66 | 9.54 | 10.76 | 0.034 | |
| 12.14_912.39 | 2.14 | 9.69 | 10.56 | 0.00 | 0.00 | 0.020 | |
| 2.79_367.71 | 2.04 | 9.12 | 10.56 | 0.00 | 0.00 | 0.027 | |
| 5.83_719.64 | 2.54 | 0.00 | 0.00 | 13.05 | 12.30 | 0.004 | |
| 3.34_877.71 | 1.92 | 1.93 | 6.11 | 14.62 | 16.73 | 0.040 | |
| 5.96_913.52 | 2.33 | 0.00 | 0.00 | 9.74 | 10.60 | 0.010 | |
| 2.73_627.94 | 1.70 | 7.51 | 9.94 | 0.00 | 0.00 | 0.050 | |
| 2.25_798.51 | 2.02 | 0.00 | 0.00 | 20.04 | 28.36 | 0.039 | |
| 2.71_501.43 | 2.34 | 0.00 | 0.00 | 8.52 | 9.19 | 0.009 | |
| 7.16_807.46 | 2.32 | 0.00 | 0.00 | 6.22 | 6.78 | 0.010 | |
| PSs | 13.60_782.52 | 2.35 | 48.23 | 37.83 | 104.02 | 52.04 | 0.018 |
| 15.05_741.50 | 2.44 | 11.11 | 9.65 | 24.79 | 11.20 | 0.013 | |
| 12.92_879.50 | 2.45 | 3.65 | 7.03 | 18.01 | 14.25 | 0.013 | |
| 12.84_815.03 | 2.49 | 2.95 | 5.18 | 18.46 | 16.20 | 0.011 | |
| 13.26_822.49 | 2.43 | 4.19 | 7.38 | 20.42 | 16.66 | 0.014 | |
| 17.99_600.69 | 2.13 | 2.40 | 3.97 | 10.04 | 9.65 | 0.036 | |
| 10.48_840.46 | 2.08 | 7.75 | 9.91 | 0.00 | 0.00 | 0.043 | |
| 13.03_844.46 | 2.78 | 12.36 | 10.11 | 0.00 | 0.00 | 0.003 | |
| 13.45_786.54 | 2.50 | 11.73 | 10.59 | 0.71 | 2.03 | 0.011 | |
| 18.56_601.86 | 2.11 | 4.04 | 4.40 | 0.39 | 1.12 | 0.038 | |
| 13.09_874.69 | 2.04 | 7.73 | 8.80 | 0.76 | 2.16 | 0.045 | |
| 14.40_838.03 | 2.04 | 10.66 | 13.79 | 0.00 | 0.00 | 0.045 | |
| 12.85_841.74 | 2.12 | 0.81 | 2.56 | 8.56 | 10.51 | 0.038 | |
| 17.02_688.96 | 2.23 | 0.56 | 1.79 | 7.07 | 8.23 | 0.026 | |
| 14.85_596.55 | 2.26 | 0.55 | 1.74 | 9.20 | 10.95 | 0.025 | |
| 13.81_716.64 | 2.22 | 0.78 | 2.46 | 6.97 | 7.66 | 0.028 | |
| 16.79_744.77 | 2.01 | 2.48 | 3.29 | 0.00 | 0.00 | 0.050 | |
| 13.76_748.40 | 2.47 | 0.00 | 0.00 | 5.36 | 5.99 | 0.012 | |
| 10.50_467.35 | 2.23 | 0.00 | 0.00 | 4.43 | 5.76 | 0.026 | |
| 14.58_798.73 | 2.29 | 0.00 | 0.00 | 3.66 | 4.59 | 0.022 | |
| 18.36_614.29 | 2.08 | 2.34 | 3.07 | 0.00 | 0.00 | 0.048 | |
| 18.81_810.59 | 2.03 | 2.71 | 3.58 | 0.00 | 0.00 | 0.049 | |
| 14.83_443.05 | 2.45 | 0.00 | 0.00 | 2.89 | 3.28 | 0.013 | |
| 19.61_732.99 | 2.43 | 0.00 | 0.00 | 3.20 | 3.68 | 0.014 | |
| 12.03_992.42 | 2.03 | 2.41 | 3.17 | 0.00 | 0.00 | 0.048 | |
Bold type indicates confirmed biomarkers. Lipids are reported as a combination of RT_m/z.
NRP, not responder; PC, phosphatidylcholine; RP, responder; RT_m/z, retention time and mass/charge; SM, sphingomyelin; SD, standard deviation; PE, phatidylethanolamine; PG, phosphatidylglycerol; PS, phosphatidylserine; VIP, variable important for the projection.