Table 2.
SBRT reirradiation treatment characteristics and gastrointestinal toxicity occurrence
| Patient No. | Time from prior CRT (mo) | Prior resection | Prior RT |
(Reirradiation) SBRT |
GI toxicity∗ |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dose (Gy) | No. of fractions | Recurrence Treated Location | Treatment machine | Dose (Gy) | No. of fractions | PTV (cm3) | Acute (Grade) | Late (Grade) | Type of toxicity | |||
| 1 | 21 | No | 51 | 28 | Pancreatic tail | CyberKnife | 25 | 1 | 21.5 | - | - | - |
| 2 | 3 | No | 50.4 | 28 | Pancreatic head | CyberKnife | 25 | 1 | 20.0 | - | - | - |
| 3 | 4 | No | 60 | 30 | Pancreatic head | CyberKnife | 25 | 1 | 34.0 | 2 | - | Gastric ulcer |
| 4 | 13 | Yes | 50.4 | 28 | Pancreatic head | CyberKnife | 25 | 1 | 28.3 | - | - | - |
| 5 | 3 | No | 54 | 28 | Pancreatic head | CyberKnife | 25 | 1 | 47.0 | 3 | - | Gastric fistula |
| 6 | 3 | No | 50.4 | 28 | Pancreatic head | CyberKnife | 25 | 1 | 18.8 | - | 2 | Gastric ulcer |
| 7 | 8 | No | 45 | 25 | Pancreatic head | CyberKnife | 25 | 1 | 36.0 | - | - | - |
| 8 | 10 | No | 50.4 | 28 | Pancreatic head | CyberKnife | 12.5 | 1 | 55.3 | - | - | - |
| 9 | 14 | No | 45 | 25 | Pancreatic head | CyberKnife | 25 | 1 | 37.4 | 2 | - | Nausea |
| 10 | 2 | Yes | 50.4 | 28 | Tumor bed/soft tissue | Std Linac | 25 | 5 | 33.5 | - | - | - |
| 11 | 25 | Yes | 43.2 | 24 | Tumor bed/soft tissue | Std Linac | 25 | 5 | 15.0 | - | - | - |
| 12 | 15 | Yes | 45 | 25 | Tumor bed/soft tissue | CyberKnife | 25 | 5 | 55.4 | - | - | - |
| 13 | 32 | No | 45 | 20 | Pancreatic head | CyberKnife | 25 | 5 | 89.8 | - | - | - |
| 14 | 13 | Yes | 50.4 | 28 | Tumor bed/soft tissue | CyberKnife | 25 | 5 | 54.7 | - | - | - |
| 15 | 15 | Yes | 50.4 | 28 | Tumor bed/soft tissue | Std Linac | 25 | 5 | 47.3 | - | - | - |
| 16 | 11 | No | 50.4 | 28 | Pancreatic head | CyberKnife | 20 | 5 | 76.2 | - | - | - |
| 17 | 25 | Yes | 50.4 | 28 | Tumor bed/soft tissue | Std Linac | 25 | 5 | 81.3 | - | - | - |
| 18 | 19 | Yes | 30 | 10 | Tumor bed/soft tissue | Std Linac | 27.5 | 5 | 64.3 | - | - | - |
| 19 | 3 | Yes | 45 | 25 | Tumor bed/soft tissue | Std Linac | 25 | 5 | 46.1 | 3 | - | Gastric hemorrhage |
| 20 | 9 | No | 50.4 | 28 | Pancreatic body | Std Linac | 25 | 5 | 60.5 | 2 | - | Abdominal pain |
| 21 | 21 | Yes | 45 | 25 | Tumor bed/soft tissue | Std Linac | 25 | 5 | 14.9 | - | - | - |
| 22 | 23 | Yes | 45 | 25 | Tumor bed/soft tissue | Std Linac | 33 | 5 | 46.7 | - | - | - |
| 23 | 10 | Yes | 50.4 | 28 | Regional lymph nodes | Std Linac | 25 | 5 | 29.4 | - | - | - |
SBRT, stereotactic body radiation therapy; CRT, conventional fractionated radiation therapy; RT, radiation therapy; PTV, planning target volume; GI, gastrointestinal.
∗
Grade 2 or higher according to the National Cancer Institute Common Terminology Criteria for Adverse Event, Version 4.18