Table 1.
Description of Study Population at Baseline
| Characteristic | Placebo and Cognitive Training (n = 14) |
D-Cycloserine and Cognitive Training (n = 16) |
P Value |
|---|---|---|---|
| Demographic characteristics | |||
| Age, median (range), y | 55 (37–63) | 59 (49–63) | .06 |
| Female sex, No. (%) | 6 (43) | 8 (50) | .70 |
| Race, No. (%) | |||
| White | 11 (79) | 16 (100) | .09 |
| Other | 3 (21) | 0 | |
| Education, median (range), y | 17 (14–18) | 16 (12–20) | .39 |
| Tinnitus characteristics at baseline | |||
| Duration of tinnitus, median (range), y | 10.0 (5–57) | 4.8 (1–37) | .047 |
| Subjective loudness, median (range) | 6 (4–10) | 7 (3–9) | .85 |
| Effort to ignore, No. (%) | |||
| Can never ignore | 3 (21) | 3 (19) | .48 |
| Considerable effort | 1 (7) | 2 (12) | |
| Some effort | 10 (71) | 8 (50) | |
| Slight effort | 0 | 3 (19) | |
| TFI score, median (range) | 44 (14–65) | 47 (10–76) | .66 |
| Bother level, No. (%) | |||
| Extremely bothered | 0 | 0 | .46 |
| Bothered a lot | 4 (29) | 6 (38) | |
| Bothered more than a little but not a lot | 8 (57) | 10 (63) | |
| Bothered a little, but not much | 2 (14) | 0 | |
| Not bothered | 0 | 0 | |
| PHQ-9 score, median (range) | 4 (0–10) | 5 (1–11) | .74 |
| Cognitive assessments, median (range) | |||
| CFQ score | 43 (19–60) | 41 (18–51) | .85 |
| Stroop Color-Word T-score | 58 (43–64) | 54 (40–71) | .28 |
| PASAT, No. correct | 156 (68–194) | 128 (65–229) | .48 |
Abbreviations: CFQ, Cognitive Failures Questionnaire; PASAT, Paced Auditory Serial Addition Test; PHQ-9, Patient Health Questionnaire-9; TFI, Tinnitus Functional Index.