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. Author manuscript; available in PMC: 2017 Jul 18.
Published in final edited form as: Arthritis Rheumatol. 2016 May;68(5):1301–1313. doi: 10.1002/art.39538

Figure 6.

Figure 6

Model of short term acute and local inflammatory stimulus (TNFα)-induced osteoclastogenesis in CD97 KO mice. TNFα treatment augmented the expression of CD97 to suppress excess osteoclastogenesis in WT mice while TNF treatment markedly enhanced various cytokines and chemokine in addition to increasing the RANKL and reducing OPG expression in the absence of CD97 to increase in osteoclast formation in bone marrow cavity of calvaria. Blue arrow indicates the possible cell autonomous effect of osteoclasts in response to TNFα.