Table 1.
Senolytic agents and the Senescent Cell Anti-apoptotic Pathways (SCAPs) and cell types they target.
| Senolytic | SCAP | Target senescent cell types |
|---|---|---|
| Dasatinib (D) | Dependence receptor/Src kinase/tyrosine kinase | Primary human and mouse preadipocytes (adipose-derived stem cells) |
| Quercetin (Q) | Bcl-2 family, p53/p21/serpine, & PI3K/AKT | HUVECs, mouse bone marrow-derived mesenchymal stem cells |
| D + Q | Dependence receptor/Src kinase/tyrosine kinase, Bcl-2 Family, p53/p21/serpine, & PI3K/AKT | As for D + Q plus primary human lung fibroblasts and mouse embryonic fibroblasts |
| Navitoclax (ABT263) | Bcl-2 family (Bcl-2, Bcl-xL, Bcl-w) | IMR-90 Cells, HUVECs |
| Piperlongumine | p53/p21 & Bcl-2 family (Bcl-2 binding component 3, also known as PUMA) | WI-38 Cells |
| A1331852 | Bcl-2 family (Bcl-xL) | IMR-90 Cells, HUVECs |
| A1155463 | Bcl-2 family (Bcl-xL) | IMR-90 Cells, HUVECs |
| Fisetin | PI3K/AKT | HUVECs |
| FOXO4-related peptide | Bcl-2 family & p53/p21/serpine | IMR-90, WI-38, BJ cells |