Fig. 5.

In HLA-B*57 + ECs, the frequency of HIV-specific B cells correlates with the neutralization of tier-2 T/F virus.

(a) Association of HIV gp140-specific B cell frequency (among IgG + B cells) and percent of neutralization for all HIV strains tested (top panel) or T/F HIV strains (bottom panel) for all ECs (Total EC), HLA-B*57 + and HLA-B*57 − ECs. (*) p < 0.05. (b) Spearman correlation matrices between the frequency of gp140- and gp41-specific B cell of various IgG isotypes and the percentage of neutralized strains (All strains) or T/F strains and the frequency of Env-specific B cell of various IgG subtypes. Left panel HLA-B*57 + and right panel HLA-B*57 − ECs. Strength and significance are represented as size and color intensity: blue for positive correlation and red for negative correlation. The numbers are p values.