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. 2017 May 23;21:206–212. doi: 10.1016/j.ebiom.2017.05.024

Fig. 2.

Fig. 2

a) Effects on coronary perfusion pressure (CPP) of carfilzomib administered at three different concentrations (10− 9, 10− 8 and 10− 7 mol/L) by injection of 1 cc boluses over 5 min using a collateral arm of the perfusion cannula. *p < 0.05, **p < 0.01 versus bolus injections of 1 cc buffer over a time frame of 5 min. Baseline value of CPP was recorded during buffer perfusion through the aortic inflow cannula at a constant rate of 22–24 ml/min. b) Effects on left ventricular pressure (LVP) and heart rate (HR) of carfilzomib administered at three different concentrations (10− 9, 10− 8 and 10− 7 mol/L) by injection of 1 cc boluses over 5 min using a collateral arm of the perfusion cannula.