Fig. 5.

Broad-spectrum anti-streptococcal activity of calprotectin. Growth characteristics of streptococcal pathogens, a) group B streptococcus (S. agalactiae), b) group C streptococcus (S. dysgalactiae), c) group G streptococcus (S. dysgalactiae subsp. equisimilis), d) S. mutans, e) S. pneumoniae, f) Enterococcus faecalis, g) Listeria monocytogenes, was assessed. Bacteria were grown in triplicate in medium supplemented with the indicated concentrations of CP. Growth was monitored by absorption at A₆₀₀ in a microplate reader at the indicated time points. h) Amino acid sequence conservation of AdcA, AdcB, and AdcC proteins among different streptococcal pathogens. The respective amino acid sequence identities and chemical similarities relative to GAS sequences are shown. The protein identification number of the respective proteins is given in parentheses.