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. 2017 Mar 8;3(7):492–501. doi: 10.1021/acsinfecdis.7b00017

Figure 3.

Figure 3

Location of amino acid sequence polymorphisms in (A) PanD and (B) ClpC1 of POA-resistant M. tuberculosis strains isolated from POA-treated mice. (A) Domain organization of PanD is shown as described in ref (20). The conserved autocleavage site between residues 24 (Gly) and 25 (Ser) in the aspartate decarboxylase domain is indicated. (B) Domain organization of ClpC1 is shown as described in ref (35). Within the N-terminal domain, two repeats are labeled I and II. A and B in the D1 and D2 domains indicate Walker A and Walker B motifs, respectively. The nine POA-resistant M. tuberculosis strains subjected to whole genome sequencing and described in Table 1 are labeled in bold.