Table 4  Survival analyses relative to SNP rs3817198, showing adjusted* hazard ratios (HRs) with 95% confidence intervals (CIs) and corresponding p values.

Patients	Genotype	Overall survival		Progression-free survival
		HR (95% CI)	p value	HR (95% CI)	p value
* HRs for molecular subtypes were adjusted for age, BMI, tumor stage, nodal status, and tumor type. The “overall” HR representing the prognostic effect across the hormone receptor subgroups was adjusted in the same way as the HRs for molecular subtypes and additionally for ER, PR, HER2, and grading. All results are based on the genetic interaction model for overall and progression-free survival.
HER2-positive	Homozygous common	1 (reference)		1 (reference)
	Heterozygous	0.70 (0.24, 2.05)	0.51	0.51 (0.23, 1.11)	0.09
	Homozygous rare	0.84 (0.16, 4.43)	0.85	0.46 (0.13, 1.61)	0.22
Triple- negative	Homozygous common	1 (reference)		1 (reference)
	Heterozygous	0.71 (0.29, 1.70)	0.44	0.71 (0.35, 1.44)	0.34
	Homozygous rare	0.03 (0.002, 0.279)	< 0.01	0.09 (0.02, 0.36)	< 0.001
Luminal A-like	Homozygous common	1 (reference)		1 (reference)
	Heterozygous	0.85 (0.36, 2.02)	0.71	0.73 (0.37, 1.43)	0.36
	Homozygous rare	0.24 (0.04, 1.43)	0.12	0.19 (0.05, 0.84)	0.03
Luminal B-like	Homozygous common	1 (reference)		1 (reference)
	Heterozygous	1.38 (0.69, 2.78)	0.36	1.36 (0.83, 2.23)	0.22
	Homozygous rare	1.03 (0.29, 3.73)	0.96	2.13 (1.02, 4.40)	0.04
Overall	Homozygous common	1 (reference)		1 (reference)
	Heterozygous	0.80 (0.41, 1.57)	0.52	0.65 (0.39, 1.10)	0.11
	Homozygous rare	0.41 (0.10, 1.69)	0.22	0.36 (0.13, 1.03)	0.06