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. 2017 Jul 14;37(15):e00063-17. doi: 10.1128/MCB.00063-17

FIG 13.

FIG 13

CDDO-Im treatment reduces IFN-γ production. (A) Frequencies of effector T cell subsets in the LNs of vehicle-treated WT (n = 5), CDDO-Im-treated WT (n = 4), vehicle-treated Sf (n = 7), and CDDO-Im-treated Sf (n = 7) mice. The percentages of the IFN-γ+, IL-4+, IL-17A+, and IL-10+ fractions of CD4 single-positive cells and of the IFN-γ+ fraction of CD8 single-positive cells are shown. The values represent the means and SD. (B) Representative contour plot data for the IFN-γ+, IL-4+, IL-17A+, and IL-10+ fractions of CD4 single-positive LN cells and the IFN-γ+ fraction of CD8 single-positive LN cells, with the percentages of cytokine-positive fractions shown. (C) Ifng gene expression in the spleens of vehicle-treated WT (n = 4), CDDO-Im-treated WT (n = 4), vehicle-treated Sf (n = 4), and CDDO-Im-treated Sf (n = 4) mice. The expression levels were normalized to Gapdh expression, and the expression level in vehicle-treated WT mice was set to 1. The values represent the means and SD. NS, not significant; *, P < 0.05; **, P < 0.005; ***, P < 0.0005.