FIG 4.
Systemic NRF2 activation inhibits the activation of T cells in Sf mice. (A) Ratios of the weights of the spleens and LNs (bilateral axillary, brachial, and inguinal LNs) to the whole-body weights of WT (n = 10), Sf (n = 10), and Sf::Keap1FA/− (n = 10) mice at 17 days of age. The values represent the means and SD. (B) Macroscopic observation of the spleens and LNs of WT, Sf, and Sf::Keap1FA/− mice. (C) Frequencies of T cell populations in the LNs of WT (n = 5), Sf (n = 4), and Sf::Keap1F/− (n = 8) mice. Percentages of CD4 and CD8 single-positive cells in LN cells (left) and percentages of CD25+, CD44+, and CD69+ cells in CD4 single-positive cells (right) are shown. The values indicate the means and SD. (D) Representative histogram data for CD4 single-positive LN cells from WT, Sf, and Sf::Keap1FA/− mice at 15 to 19 days of age, with percentages of CD25+, CD44+, and CD69+ cells. NS, not significant; *, P < 0.05; **, P < 0.005; ***, P < 0.0005.