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. 2017 Jul 17;16:123. doi: 10.1186/s12943-017-0702-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — CASC2 expression was downregulated in HCC. a The expression of CASC2 in tumor tissues was significantly lower than that in adjacent nontumor tissues. b The expression of CASC2 in aggressive tumor tissues was significantly lower than that in nonaggressive cases. c The expression of CASC2 in HCC tissues with recurrence was significantly lower than that in HCC tissues without recurrence. d CASC2 expression was downregulated in HCC cell lines compared to normal hepatocyte LO2. *P < 0.05, **P < 0.01, ***P < 0.001