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. 2017 Jul 17;16:123. doi: 10.1186/s12943-017-0702-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — CASC2 inhibited migration and invasion of HCC cells both in vitro and in vivo. a pcDNA/CASC2 could significantly increase CASC2 expression in MHCC-97H cells. b CASC2-siRNAs could significantly decrease CASC2 expression in Hep-3B cells. c Transwell assays showed that CASC2 restoration decreased migration and invasion abilities of MHCC-97H cells. d CASC2 knockdown facilitated migration and invasion of Hep-3B cells. e Representative pictures showed lung metastasis of HCC in mouse model (magnification: ×100). Black arrow showed the position of lung metastasis (left panels). Quantitative analysis was used to compare the lung metastasis nodules between these two groups (right panels). *P < 0.05, **P < 0.01