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. 2017 Jul 17;16:123. doi: 10.1186/s12943-017-0702-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — CASC2 suppressed the EMT progression of HCC cells. a Immunohistochemistry analysis (magnification: ×400; Scale bar:100 μm) showed that HCC tissues in high CASC2 group presented higher E-cadherin expression and lower Vimentin expression compared to those in low CASC2 group. b CASC2 restoration significantly increased E-cadherin expression and decreased Vimentin expression in MHCC-97H cells. c CASC2 silencing could significantly decreased E-cadherin expression and increased Vimentin expression in Hep-3B cells. *P < 0.05, **P < 0.01, ***P < 0.001