Table 3.
Univariable analysis of potential predictors of death amongst transplant recipients (n = 438)
| Variable | Number | Number of deaths (%) | Death rate per 100,000 patient days (95% CI) | p-value |
|---|---|---|---|---|
| All cases | 438 | 55 (12.6) | 7.9 (6.0, 10.2) | |
| Transplant Hospital | ||||
| SCGH | 232 | 29 (12.5) | 7.9 (5.5, 11.3) | 1.0 |
| RPH | 206 | 26 (12.6) | 7.8 (5.3, 11.5) | |
| CMV viral load of ≥600 copies/ml | ||||
| No | 364 | 35 (9.6) | 5.8 (4.2, 8.0) | <0.001 |
| Yes | 74 | 20 (27.0) | 21.0 (13.6, 32.6) | |
| CMV viral load (copies/ml) | ||||
| < 600 | 364 | 35 (9.6) | 5.8 (4.2, 8.0) | |
| 600–4999 | 42 | 10 (23.8) | 18.7 (9.7, 35.9) | <0.001 |
| ≥ 5000 | 32 | 10 (31.3) | 23.5 (13.0, 42.4) | 0.001 |
| Sex | ||||
| Female | 166 | 25 (15.1) | 9.2 (6.2, 13.7) | 0.30 |
| Male | 272 | 30 (11.0) | 7.0 (4.9, 10.0) | |
| Deceased donor | ||||
| No | 192 | 17 (8.9) | 5.2 (3.2, 8.3) | 0.02 |
| Yes | 246 | 38 (15.5) | 10.2 (7.4, 14.0) | |
| Donor aged ≥60 | ||||
| No | 317 | 35 (11.0) | 6.8 (4.9, 9.5) | 0.10 |
| Yes | 121 | 20 (16.5) | 10.8 (7.0, 16.8) | |
| Graft failure | ||||
| No | 390 | 47 (12.1) | 7.6 (5.7, 10.1) | 0.51 |
| Yes | 48 | 8 (16.7) | 9.7 (4.9, 19.4) | |
| Age ≥ 65 at transplant | ||||
| No | 399 | 42 (10.5) | 6.5 (4.8, 8.8) | <0.001 |
| Yes | 39 | 13 (33.3) | 24.2 (14.1, 41.7) | |
| Lung Disease | ||||
| No | 378 | 41 (10.9) | 6.8 (5.0, 9.2) | 0.02 |
| Yes | 60 | 14 (23.3) | 14.6 (8.6, 24.6) | |
| Cerebrovascular disease | ||||
| No | 407 | 41 (10.1) | 6.2 (4.6, 8.4) | <0.001 |
| Yes | 31 | 14 (45.1) | 34.5 (20.4, 58.3) | <0.001 |
| Vascular disease other than cerebrovascular | ||||
| No | 104 | 36 (10.8) | 6.7 (4.8, 9.3) | 0.05 |
| Yes | 334 | 19 (18.3) | 11.7 (7.5, 18.4) | |
| Diabetes | ||||
| No | 293 | 35 (12.0) | 7.5 (5.4, 10.4) | 0.61 |
| Yes | 145 | 20 (13.8) | 8.6 (5.6, 13.3) | |
| HLA mismatch ≥2 | ||||
| No | 373 | 6 (10.2) | 5.9 (2.6, 13.1) | 0.45 |
| Yes | 59 | 49 (13.1) | 8.3 (6.2, 10.9) | |
| Maximum Panel Reactive Antibody level ≥ 50% | ||||
| No | 366 | 46 (12.6) | 7.8 (5.8, 10.4) | 0.62 |
| Yes | 61 | 9 (14.8) | 9.2 (4.8, 17.7) | |
| Any cancer diagnosis | ||||
| No | 352 | 42 (11.9) | 7.5 (5.5, 10.2) | 0.51 |
| Yes | 86 | 13 (15.1) | 9.2 (5.3, 15.8) | |
| Aboriginal | ||||
| No | 387 | 40 (10.3) | 6.4 (4.7, 8.8) | 0.001 |
| Yes | 51 | 15 (29.4) | 19.3 (11.6, 32.0) | |
| Any rejection | ||||
| No | 302 | 37 (12.3) | 7.9 (5.7, 10.9) | 0.99 |
| Yes | 136 | 18 (13.2) | 7.8 (4.9, 12.4) | |
| Severe rejection | ||||
| No | 404 | 49 (12.1) | 7.7 (5.8, 10.1) | 0.54 |
| Yes | 34 | 6 (17.7) | 9.9 (4.4, 21.9) | |
| Healthy weight (BMI 19–25) at transplant | ||||
| No | 272 | 35 (12.9) | 8.3 (5.9, 11.5) | 0.78 |
| Yes | 159 | 20 (12.6) | 7.6 (4.9, 11.8) | |
| Current smoker | ||||
| No | 398 | 48 (12.1) | 7.6 (5.7, 10.1) | 0.45 |
| Yes | 40 | 7 (17.5) | 10.2 (4.9, 21.5) | |