Table 4.
Cytotoxic activity of saponins fractions (100 μg/ml) from Z. armatum using NRU assay
| Fractions (100 μg/ml) | Percentage growth inhibition of cancer cells (Mean ± Std. Dev.) | |||
|---|---|---|---|---|
| MCF-7 cells | MDA MB-468 cells | Caco-2 cells | Vehicle Control | |
| Zf.Sa | 81.67*** (±4.15) | 93.81*** (±2.32) | 53.16*** (±3.31) | −0.19 (±2.68) |
| Zl.Sa | 48.58 (±7.36) | 71.19 (±2.76) | 45.96 (±10.67) | 4.23 (±7.80) |
| Zb.Sa | 7.77 (±4.83) | 95.25***(±4.35) | 66.43(±3.24) | 2.92(±3.20) |
| Actinomycin-D (4 μM) | 91.84*** (±3.73) | 93.94*** (±5.02) | 65.97** (±4.83) | 1.67 (±1.06) |
In the table statistically (Dunnett’s multiple comparison test)* = Significant (P < 0.05), ** = Highly significant (P < 0.01), *** = Very highly significant (P < 0.001)