Table 3.
Frequency of TFPI polymorphism in CAD population from two regions
| Population 1 | Population 2 | ||||||
|---|---|---|---|---|---|---|---|
| SNP | genotype | CAD n (%) | Non-CAD n (%) | P | CAD n (%) | Non-CAD n (%) | P |
| rs8176528 | 808 | 829 | 463 | 458 | |||
| GG | 656 (81.2) | 694 (83.7) | 0.146 | 380 (82.1) | 384 (83.8) | 0.486 | |
| AA GA |
40 (5.0) 112 (13.8) |
46 (5.6) 89 (10.7) |
18 (3.9) 65 (14.0) |
21 (4.6) 53 (11.6) |
|||
| Allelic A frequency (%) | 11.8 | 10.9 | 10.9 | 10.3 | |||
| rs10153820 | 808 | 829 | 463 | 458 | |||
| GG | 415 (51.4) | 420 (50.7) | 0.792 | 285 (61.6) | 286 (62.5) | 0.959 | |
| AA GA |
48 (5.9) 345 (42.7) |
56 (6.7) 353 (42.6) |
81 (17.5) 97 (20.9) |
79 (17.2) 93 (20.3) |
|||
| Allelic A frequency (%) | 27.3 | 28.0 | 27.9 | 27.4 | |||
| rs6434222 | 808 | 829 | 463 | 458 | |||
| TT | 433 (53.6) | 496 (59.8) | <0.001 | 235 (50.7) | 285 (62.2) | <0.001 | |
| AA TA |
48 (5.9) 327 (40.5) |
99 (11.9) 234 (28.3) |
11 (2.4) 217 (46.9) |
60 (13.1) 113 (24.7) |
|||
| Allelic A frequency (%) | 26.2 | 26.1 | 25.8 | 25.4 | |||
| rs7586970 | 808 | 829 | 463 | 458 | |||
| TT | 681 (84.3) | 703 (84.8) | 0.020 | 384 (82.9) | 391 (85.4) | 0.018 | |
| CC TC |
36 (4.5) 91 (11.2) |
57 (6.9) 69 (8.3) |
21 (4.5) 58 (12.6) |
32 (7.0) 35 (7.6) |
|||
| Allelic C frequency (%) | 10.1 | 11.0 | 10.8 | 10.8 | |||
Calculations are performed with comparison of three different genotypes. Values are the number (percentage) of subjects. Significant differences were drawn in frequencies of rs7586970 and rs6434222 between CAD cases and non-CAD controls