Table 2.

RWR performance for gene-sign prediction, according to general HPO classes

Clinical sign class	N° pairs	AUC (%)
Neoplasm	235	80.77
Abnormality of blood and blood-forming tissues	566	77.02
Abnormality of the endocrine system	307	74.56
Abnormality of the cardiovascular system	1027	73.84
Abnormality of the immune system	609	72.91
Abnormality of the integument	1155	72.68
Abnormality of metabolism/homeostasis	953	72.15
Abnormality of the musculature	895	69.47
Abnormality of the abdomen	1444	68.45
Abnormality of connective tissue	293	67.99
Abnormality of the skeletal system	3460	67.52
Abnormality of head and neck	4071	67.33
Abnormality of the respiratory system	406	67.17
Abnormality of the genitourinary system	1182	66.55
Abnormality of the ear	628	65.74
Growth abnormality	547	65.71
Abnormality of the nervous system	3995	64.70
Abnormality of the eye	1908	64.39