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. Author manuscript; available in PMC: 2017 Jul 18.
Published in final edited form as: Biochem J. 2015 Aug 1;469(3):347–355. doi: 10.1042/BJ20150568

Figure 3. Cross regulation of autophagy and KEAP1-NRF2.

Figure 3

KEAP1 can also interact with p62. This interaction sequesters KEAP1 away from NRF2, preventing NRF2 ubiquitination and degradation. NRF2 stabilization and translocation to the nucleus allows its transcriptional activity. One of the NRF2 target genes is p62 which sequesters KEAP1 and brings it to be degraded by autophagy. This positive loop plays a role in coordinating autophagy and NRF2 activities.