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. Author manuscript; available in PMC: 2018 Jan 23.
Published in final edited form as: Nat Microbiol. 2017 Jan 23;2:16267. doi: 10.1038/nmicrobiol.2016.267

Figure 2. Mesalamine reduces polyP levels in gut microbiota.

Figure 2

a, Steady-state polyP levels and mesalamine concentrations in GI luminal samples of healthy human subjects following oral mesalamine administration. Data for each subject represent two technical replicates and the mean. b, PolyP levels in nutrient-shifted bacteria cultivated from faecal content of healthy human subjects following ex vivo mesalamine treatment. Data represent the mean ± s.d. ****P < 0.0001 (ratio paired t-test). c, Steady-state polyP levels in stool samples of healthy human subjects after 60 min of ex vivo treatment with 250 µM mesalamine. Data for each subject represent two technical replicates and the mean. Detailed information about the statistical analyses is provided in the Methods.